A PHYLOGENETIC SURVEY OF MYOTUBULARIN GENES OF EUKARYOTES: DISTRIBUTION, PROTEIN STRUCTURE, EVOLUTION, AND GENE EXPRESSION

Abstract Background Phosphorylated phosphatidylinositol (PtdIns) lipids, produced and modified by PtdIns kinases and phosphatases, are critical to the regulation of diverse cellular functions.The myotubularin PtdIns-phosphate phosphatases have been well characterized in yeast and especially animals, where multiple isoforms, both catalytically activ

BackgroundAlcohol misuse, binge drinking pattern, and gender-specific effects in the middle-aged population has been clearly underestimated.In the present study, we focused on understanding gender-specific effects of alcohol exposure on the gut-liver axis and the role of gut microbiota in modulating gender-specific responses to alcohol consumption.